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We performed a genome-wide scan to localize genes involved in the development of oral lichen planus. We found that 6q22-23 was the locus of maximum linkage to oral lichen planus and a novel candidate gene, fibroblast growth factor 13 (FGF13), was mapped within the 1-LOD support interval. Three single nucleotide polymorphisms (SNPs) in exon 1 (5-repeat/non-5-repeat; rs2699775; R620G), intron 2 (G1264A; rs2208854) and exon 5 (T1073C; rs2201690) of the FGF13 gene were found. Both the 5-repeat and non-5-repeat alleles of the 5-repeat allele/T1073C SNP were associated with oral lichen planus in cases. The polymorphisms were also found in the peripheral blood of healthy Japanese donors. The FGF13 gene was expressed in normal human oral mucosa, squamous cell carcinoma (SCC) cell lines, and normal human fibroblasts, and its expression was up-regulated in SCC cell lines. The present study suggests that the FGF13 gene may be involved in the development of oral lichen planus.[Peripartum cardiomyopathy].
Peripartum cardiomyopathy is a severe form of heart failure in women in the puerperal period. The disease begins within one or two weeks before delivery and may last for several weeks after delivery. This disorder is one of the major causes of hospitalization in obstetrics. Its etiology remains unknown. Diagnosis of peripartum cardiomyopathy is established by clinical and echocardiographic criteria. Symptoms and clinical signs include the presence of heart failure (symptomatic and asymptomatic) and the diagnosis ac619d1d87
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